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Article

Gamma radiation increases endonuclease-dependent L1 retrotransposition in a cultured cell assay.

Nucleic acids research - 1 Jan 2006

Farkash Evan A, Kao Gary D, Horman Shane R, Prak Eline T Luning

Abstract excerpt

Long Interspersed Elements (LINE-1s, L1s) are the most active mobile elements in the human genome and account for a significant fraction of its mass. The propagation of L1 in the human genome requires disruption and repair of DNA at the site of integration. As Barbara McClintock first hypothesized, genotoxic stress may contribute to the mobilization of transposable elements, and conversely, element mobility may...

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Identifiers

PMID: 16507671
DOI: 10.1093/nar/gkj522
PMCID: PMC1385994

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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