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Thrombopoietin protects hematopoietic stem cells from retrotransposon-mediated damage by promoting an antiviral response

3 Apr 2018

Abstract excerpt

Maintenance of genomic integrity is crucial for the preservation of hematopoietic stem cell (HSC) potential. Retrotransposons, spreading in the genome through an RNA intermediate, have been associated with loss of self-renewal, aging, and DNA damage. However, their role in HSCs has not been addressed. Here, we show that mouse HSCs express various retroelements (REs), including long interspersed element-1 (L1)...

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PMID: 29615469
DOI: 10.1084/jem.20170997

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