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Article

Mutant DnaAs of Escherichia coli that are refractory to negative control.

Nucleic acids research - 1 Dec 2013

Chodavarapu Sundari, Felczak Magdalena M, Simmons Lyle A, Murillo Alec, Kaguni Jon M

Abstract excerpt

DnaA is the initiator of DNA replication in bacteria. A mutant DnaA named DnaAcos is unusual because it is refractory to negative regulation. We developed a genetic method to isolate other mutant DnaAs that circumvent regulation to extend our understanding of mechanisms that control replication initiation. Like DnaAcos, one mutant bearing a tyrosine substitution for histidine 202 (H202Y) withstands the regulation...

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Identifiers

PMID: 23990329
DOI: 10.1093/nar/gkt774
PMCID: PMC3905854

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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