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Article

In vitro RNA interference against beta-catenin inhibits the proliferation of pediatric hepatic tumors.

International journal of oncology - 1 Mar 2006

Sangkhathat Surasak, Kusafuka Takeshi, Miao Jiangyong, Yoneda Akihiro, Nara Keigo, Yamamoto Seiji, Kaneda Yasafumi, Fukuzawa Masahiro

Abstract excerpt

Mutations of beta-catenin have been identified in the majority of pediatric hepatic malignancies, including hepatoblastoma (HB) and hepatocellular carcinoma (HCC), suggesting its important contribution in hepatic tumorigenesis in this age group. However, the role of beta-catenin/canonical Wnt signaling pathway in the neoplastic growth of cancer cells has not been directly studied. To address beta-catenin's...

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PMID: 16465377

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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