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Article

Tbx3 is a downstream target of the Wnt/beta-catenin pathway and a critical mediator of beta-catenin survival functions in liver cancer.

Cancer research - 1 Feb 2007

Renard Claire-Angélique, Labalette Charlotte, Armengol Carolina, Cougot Delphine, Wei Yu, Cairo Stefano, Pineau Pascal, Neuveut Christine, de Reyniès Aurélien, Dejean Anne, Perret Christine, Buendia Marie-Annick

Abstract excerpt

Tbx3 encodes a transcriptional repressor that is important for diverse patterning events during development, and Tbx3 mutation in humans causes the ulnar-mammary syndrome. Here, we describe the identification of Tbx3 in array-based search for genes downstream Wnt/beta-catenin that are implicated in liver tumorigenesis. Overexpression of Tbx3 is closely associated with the mutational status of beta-catenin in...

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PMID: 17283120
DOI: 10.1158/0008-5472.CAN-06-2344

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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