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Article

Downregulation of SFRP1 is a protumorigenic event in hepatoblastoma and correlates with beta-catenin mutations.

Journal of cancer research and clinical oncology - 1 May 2020

Regel Ivonne, Eichenmüller Melanie, Mahajan Ujjwal Mukund, Hagl Beate, Benitz Simone, Häberle Beate, Vokuhl Christian, von Schweinitz Dietrich, Kappler Roland

Abstract excerpt

BACKGROUND: Hepatoblastoma (HB) and pediatric hepatocellular carcinoma (HCC) are the most common malignant liver tumors in childhood. Both tumor types exhibit genetic and epigenetic alterations in the WNT/β-catenin signaling pathway, which is a key regulator of liver progenitor cells in embryonic development. The tumors demonstrate a high rate of β-catenin mutations and gene expression changes of several WNT...

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Identifiers

PMID: 32189106
DOI: 10.1007/s00432-020-03182-1
PMCID: PMC7142044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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