Article
Targeting cadherin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinoma.
Hepatology (Baltimore, Md.) - 1 Nov 2009
Liu Ling Xiao, Lee Nikki P, Chan Vivian W, Xue Wen, Zender Lars, Zhang Chunsheng, Mao Mao, Dai Hongyue, Wang Xiao Lin, Xu Michelle Z, Lee Terence K, Ng Irene O, Chen Yangchao, Kung Hsiang-fu, Lowe Scott W, Poon Ronnie T P, Wang Jian Hua, Luk John M
Abstract excerpt
UNLABELLED: Hepatocellular carcinoma (HCC) is a lethal malignancy for which there are no effective therapies. To develop rational therapeutic approaches for treating this disease, we are performing proof-of-principle studies targeting molecules crucial for the development of HCC. Here, we show that cadherin-17 (CDH17) adhesion molecule is up-regulated in human liver cancers and can transform premalignant liver...
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