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Article

Complete response of Ctnnb1-mutated tumours to β-catenin suppression by locked nucleic acid antisense in a mouse hepatocarcinogenesis model.

Journal of hepatology - 1 Feb 2015

Delgado Evan, Okabe Hirohisa, Preziosi Morgan, Russell Jacquelyn Olivia, Alvarado Tamara Feliciano, Oertel Michael, Nejak-Bowen Kari Nichole, Zhang Yixian, Monga Satdarshan P S

Abstract excerpt

BACKGROUND & AIMS: Hepatocellular cancer (HCC) remains a disease of poor prognosis, highlighting the relevance of elucidating key molecular aberrations that may be targeted for novel therapies. Wnt signalling activation, chiefly due to mutations in CTNNB1, have been identified in a major subset of HCC patients. While several in vitro proof of concept studies show the relevance of suppressing Wnt/β-catenin...

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Source

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Identifiers

PMID: 25457204
DOI: 10.1016/j.jhep.2014.10.021
PMCID: PMC4300253

Genes

CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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