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Article

Diagnostic and prognostic impact of beta-catenin alterations in pediatric liver tumors.

Oncology reports - 1 Mar 2006

Yamaoka Hiroaki, Ohtsu Kazuhiro, Sueda Taijiro, Yokoyama Takashi, Hiyama Eiso

Abstract excerpt

Hepatoblastoma (HBL), a major childhood malignant neoplasm, represents the most frequent malignant liver tumor in childhood. Recent reports have shown the CTNNB1 coding beta-catenin protein to be frequently mutated or deleted at hot-spot regions involving exon 3 in HBL. We investigated the genetic alterations of the CTNNB1 coding beta-catenin protein and expression of several genes downstream of Wnt signals in 4...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16465411

Genes

CTNNB1

Provenance

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