Article
Antitumour activity of an inhibitor of miR-34a in liver cancer with β-catenin-mutations.
Gut - 1 Jun 2016
Gougelet Angélique, Sartor Chiara, Bachelot Laura, Godard Cécile, Marchiol Carmen, Renault Gilles, Tores Frédéric, Nitschke Patrick, Cavard Catherine, Terris Benoit, Perret Christine, Colnot Sabine
Abstract excerpt
OBJECTIVE: Hepatocellular carcinoma (HCC) is the most prevalent primary tumour of the liver. About a third of these tumours presents activating mutations of the β-catenin gene. The molecular pathogenesis of HCC has been elucidated, but mortality remains high, and new therapeutic approaches, inclu...
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