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Article

siRNA-mediated beta-catenin knockdown in human hepatoma cells results in decreased growth and survival.

Neoplasia (New York, N.Y.) - 1 Nov 2007

Zeng Gang, Apte Udayan, Cieply Benjamin, Singh Sucha, Monga Satdarshan P S

Abstract excerpt

beta-Catenin, the chief oncogenic component of the canonical Wnt pathway, is known to be involved in a variety of cancers, including hepatocellular carcinoma (HCC). Although the mechanism of beta-catenin activation in HCC is multifactorial, it is indisputably implicated at various stages of hepatocarcinogenesis, making it an attractive therapeutic target. Here we investigate the effect of small interfering...

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Source

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Identifiers

PMID: 18030363
DOI: 10.1593/neo.07469
PMCID: PMC2077886

Genes

CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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