Article
Stabilization of beta-catenin affects mouse embryonic liver growth and hepatoblast fate.
Hepatology (Baltimore, Md.) - 1 Jan 2008
Decaens Thomas, Godard Cécile, de Reyniès Aurélien, Rickman David S, Tronche François, Couty Jean-Pierre, Perret Christine, Colnot Sabine
Abstract excerpt
UNLABELLED: During hepatogenesis, after the liver has budded out of the endoderm, the hepatoblasts quickly expand and differentiate into either hepatocytes or biliary cells, the latter of which arise only within the ductal plate surrounding the portal vein. Because the Wnt/beta-catenin pathway is involved in liver homeostasis and regeneration and in liver carcinogenesis, we investigated here a role for...
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