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Article

Stabilized beta-catenin promotes hepatocyte proliferation and inhibits TNFalpha-induced apoptosis.

Laboratory investigation; a journal of technical methods and pathology - 1 Mar 2004

Shang Xian-Zhang, Zhu Haizhen, Lin Karrie, Tu Zhengkun, Chen Jisheng, Nelson David R, Liu Chen

Abstract excerpt

The human hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. The mechanisms of liver cell oncogenic transformation are still unknown. The beta-catenin mutations are identified in up to 30% of HCC and 80% of hepatoblastoma, suggesting a potential role of beta-cate...

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PMID: 14767485
DOI: 10.1038/labinvest.3700043

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14767485-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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