Article
A common polymorphism renders the luteinizing hormone receptor protein more active by improving signal peptide function and predicts adverse outcome in breast cancer patients.
The Journal of clinical endocrinology and metabolism - 1 Apr 2006
Piersma Djura, Berns Els M J J, Verhoef-Post Miriam, Uitterlinden Andre G, Braakman Ineke, Pols Huibert A P, Themmen Axel P N
Abstract excerpt
CONTEXT: Epidemiological and animal studies indicate a carcinogenic role of estrogens in breast tissue. The pituitary gonadotropin LH is an important regulator of estrogen production in premenopausal women, whereas even in women after menopause, 10-25% of ovarian steroid hormone production is LH dependent. OBJECTIVE: We hypothesized that an LH receptor (LHR) gene variant may affect LHR function and thereby...
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