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Article

Luteinizing hormone signaling and breast cancer: polymorphisms and age of onset.

The Journal of clinical endocrinology and metabolism - 1 Apr 2003

Powell B L, Piersma D, Kevenaar M E, van Staveren I L, Themmen A P N, Iacopetta B J, Berns E M J J

Abstract excerpt

Estrogen exposure has repeatedly been shown to associate with the risk of developing breast cancer. Estrogen synthesis is under the control of LH and FSH, where LH, through its receptor (LHR), stimulates production of ovarian androgens; and FSH, their aromatization to estrogens. Here, we investigated whether functional polymorphic variants in the LH signaling pathway are associated with the risk of breast cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12679452
DOI: 10.1210/jc.2002-021585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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