Article
A comprehensive analysis of common genetic variation in prolactin (PRL) and PRL receptor (PRLR) genes in relation to plasma prolactin levels and breast cancer risk: the multiethnic cohort.
BMC medical genetics - 1 Dec 2007
Lee Sulggi A, Haiman Christopher A, Burtt Noel P, Pooler Loreall C, Cheng Iona, Kolonel Laurence N, Pike Malcolm C, Altshuler David, Hirschhorn Joel N, Henderson Brian E, Stram Daniel O
Abstract excerpt
BACKGROUND: Studies in animals and humans clearly indicate a role for prolactin (PRL) in breast epithelial proliferation, differentiation, and tumorigenesis. Prospective epidemiological studies have also shown that women with higher circulating PRL levels have an increase in risk of breast cancer, suggesting that variability in PRL may also be important in determining a woman's risk. METHODS: We evaluated genetic...
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