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Article

Association of prolactin receptor (PRLR) variants with prolactinomas

14 Nov 2018

Abstract excerpt

Prolactinomas are the most frequent type of pituitary tumors, which represent 10-20% of all intracranial neoplasms in humans. Prolactinomas develop in mice lacking the prolactin receptor (PRLR), which is a member of the cytokine receptor superfamily that signals via Janus kinase-2-signal transducer and activator of transcription-5 (JAK2-STAT5) or phosphoinositide 3-kinase-Akt (PI3K-Akt) pathways to mediate...

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PMID: 30445560
DOI: 10.1093/hmg/ddy396

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