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Synthesis, purification and structural and functional characterization of recombinant form of a common genetic variant of human luteinizing hormone.

Human molecular genetics - 1 Feb 2002

Manna Pulak R, Joshi Lata, Reinhold Vernon N, Aubert Michel L, Suganuma Nobuhiko, Pettersson Kim, Huhtaniemi Ilpo T

Abstract excerpt

A common genetic variant (V) of luteinizing hormone (LH), with two mutations (Trp(8)Arg and Ile(15)Thr) and an extra glycosylation consensus site (Asn(13)-Ala-Thr), is associated with abnormalities of reproductive function. To address the molecular basis of the functional differences between V- and wild-type (WT)-LH, recombinant (rec) forms of WT- and V-LH were synthesized in human embryonic kidney (HEK 293)...

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PMID: 11823449
DOI: 10.1093/hmg/11.3.301

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