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Article

Identification of a region within SEL1L protein required for tumour growth inhibition.

Gene - 4 Feb 2004

Cattaneo Monica, Canton Cristina, Albertini Alberto, Biunno Ida

Abstract excerpt

The ectopic expression of the entire SEL1L cDNA significantly reduces the proliferate activity and aggressive behavior of the human breast carcinoma cell line MCF-7. However, the mechanism responsible for this biological effect remains unclear. A study was initiated to define those regions within...

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Source

Identifiers

PMID: 14729273
DOI: 10.1016/j.gene.2003.10.021

Genes

TPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14729273-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Identification of a region within SEL1L protein required for tumour growth inhibition.PMID 14729273Read ↗

Functional characterization of two secreted SEL1L isoforms capable of exporting unassembled substrate.Semantic proximity Read ↗

SEL1L-HRD1 interaction is prerequisite for the formation of a functional HRD1 ERAD complexSemantic proximity Read ↗

High throughput functional genomics: identification of novel genes with tumor suppressor phenotypes.Semantic proximity Read ↗

Transcriptomic analysis of SEL1L and HRD1 knockout cell lines reveals multifaceted roles of SEL1L beyond the ER quality controlSemantic proximity Read ↗

Allelic polymorphisms in the transcriptional regulatory region of human SEL1L.Semantic proximity Read ↗

Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines.Semantic proximity Read ↗

Structural basis and pathological implications of the dimeric OS9-SEL1L-HRD1 ERAD Core Complex.Semantic proximity Read ↗

Functional integrity of the SEL1L-HRD1 complex is critical for endoplasmic reticulum-associated degradation and organismal viability.Semantic proximity Read ↗

Functional integrity of the SEL1L-HRD1 complex is critical for ERAD and organismal viabilitySemantic proximity Read ↗

Haploid insufficiency of suppressor enhancer Lin12 1-like (SEL1L) protein predisposes mice to high fat diet-induced hyperglycemia.Semantic proximity Read ↗

Deficiency of Suppressor Enhancer Lin12 1 Like (SEL1L) in Mice Leads to Systemic Endoplasmic Reticulum Stress and Embryonic LethalitySemantic proximity Read ↗

Structural basis and pathological implications of the dimeric OS9-SEL1L-HRD1 ERAD Core ComplexSemantic proximity Read ↗

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