Article
Neuronal cotransport of glycine receptor and the scaffold protein gephyrin.
The Journal of cell biology - 30 Jan 2006
Maas Christoph, Tagnaouti Nadia, Loebrich Sven, Behrend Bardo, Lappe-Siefke Corinna, Kneussel Matthias
Abstract excerpt
The dynamics of postsynaptic receptor scaffold formation and remodeling at inhibitory synapses remain largely unknown. Gephyrin, which is a multimeric scaffold protein, interacts with cytoskeletal elements and stabilizes glycine receptors (GlyRs) and individual subtypes of gamma-aminobutyric acid A receptors at inhibitory postsynaptic sites. We report intracellular mobility of gephyrin transports packets over...
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