Article
LIS1-dependent retrograde translocation of excitatory synapses in developing interneuron dendrites.
Nature communications - 6 Mar 2012
Kawabata Izumi, Kashiwagi Yutaro, Obashi Kazuki, Ohkura Masamichi, Nakai Junichi, Wynshaw-Boris Anthony, Yanagawa Yuchio, Okabe Shigeo
Abstract excerpt
Synaptic remodelling coordinated with dendritic growth is essential for proper development of neural connections. After establishment of synaptic contacts, synaptic junctions are thought to become stationary and provide fixed anchoring points for further dendritic growth. However, the possibility of active translocation of synapses along dendritic protrusions, to guide the proper arrangement of synaptic...
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