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Article

Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane.

The EMBO journal - 19 Apr 2006

Gerges Nashaat Z, Backos Donald S, Rupasinghe Chamila N, Spaller Mark R, Esteban José A

Abstract excerpt

Intracellular membrane trafficking of glutamate receptors at excitatory synapses is critical for synaptic function. However, little is known about the specialized trafficking events occurring at the postsynaptic membrane. We have found that two components of the exocyst complex, Sec8 and Exo70, separately control synaptic targeting and insertion of AMPA-type glutamate receptors. Sec8 controls the directional...

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Identifiers

PMID: 16601687
DOI: 10.1038/sj.emboj.7601065
PMCID: PMC1440842

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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