Article
The residence time of GABA(A)Rs at inhibitory synapses is determined by direct binding of the receptor α1 subunit to gephyrin.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 12 Oct 2011
Mukherjee Jayanta, Kretschmannova Karla, Gouzer Geraldine, Maric Hans-Michael, Ramsden Sarah, Tretter Verena, Harvey Kirsten, Davies Paul A, Triller Antoine, Schindelin Hermann, Moss Stephen J
Abstract excerpt
The majority of fast synaptic inhibition in the brain is mediated by benzodiazepine-sensitive α1-subunit-containing GABA type A receptors (GABA(A)Rs); however, our knowledge of the mechanisms neurons use to regulate their synaptic accumulation is rudimentary. Using immunoprecipitation, we demonstrate that GABA(A)Rs and gephyrin are intimately associated at inhibitory synapses in cultured rat neurons. In vitro we...
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