Article

Gephyrin filaments represent the molecular basis of inhibitory postsynaptic densities

2025-03-13

Abstract excerpt

<title>Abstract</title> <p>The multifunctional protein gephyrin clusters glycine and GABA type A receptors at the postsynaptic membrane in the CNS. Gephyrin has been proposed to form the inhibitory postsynaptic density by liquid-liquid phase separation, involving a complex interplay between receptor binding and oligomerization via its conserved G- and E-domains. Our single particle cryo-EM analyses uncovered that...

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Literature Corpus work: 723f0bfa-d92d-5dfd-b85c-7659b60316be
DOI: 10.21203/rs.3.rs-5889959/v1

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