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Article

Rapid and selective binding to the synaptic SNARE complex suggests a modulatory role of complexins in neuroexocytosis.

The Journal of biological chemistry - 8 Mar 2002

Pabst Stefan, Margittai Martin, Vainius Darius, Langen Ralf, Jahn Reinhard, Fasshauer Dirk

Abstract excerpt

The Ca(2+)-triggered release of neurotransmitters is mediated by fusion of synaptic vesicles with the plasma membrane. The molecular machinery that translates the Ca(2+) signal into exocytosis is only beginning to emerge. The soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins syntaxin, SNAP-25, and synaptobrevin are central components of the fusion apparatus. Assembly of a...

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Identifiers

PMID: 11751907
DOI: 10.1074/jbc.M109507200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Rapid and selective binding to the synaptic SNARE complex suggests a modulatory role of complexins in neuroexocytosis.PMID 11751907Read ↗

Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis.Semantic proximity Read ↗

The primed SNARE-complexin-synaptotagmin complex for neuronal exocytosis.Semantic proximity Read ↗

Complexin Binding to Membranes and Acceptor t-SNAREs Explains Its Clamping Effect on Fusion.Semantic proximity Read ↗

Conformational dynamics of calcium-triggered activation of fusion by synaptotagmin.Semantic proximity Read ↗

Complexins living up to their name--new light on their role in exocytosis.Semantic proximity Read ↗

Complexin is able to bind to SNARE core complexes in different assembled states with distinct affinity.Semantic proximity Read ↗

Structural transitions in the synaptic SNARE complex during Ca2+-triggered exocytosis.Semantic proximity Read ↗

SNARE complex formation is triggered by Ca2+ and drives membrane fusion.Semantic proximity Read ↗

Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.Semantic proximity Read ↗

Molecular origins of synaptotagmin 1 activities on vesicle docking and fusion pore opening.Semantic proximity Read ↗

Conserved prefusion protein assembly in regulated exocytosis.Semantic proximity Read ↗

Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity.Semantic proximity Read ↗

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