Article

Loss of postsynaptic NMDARs drives nanoscale reorganization of Munc13-1 and PSD-95

2024-01-12

Abstract excerpt

Nanoscale protein organization within the active zone (AZ) and post-synaptic density (PSD) influences synaptic transmission. Nanoclusters of presynaptic Munc13-1 are associated with readily releasable pool size and neurotransmitter vesicle priming, while postsynaptic PSD-95 nanoclusters coordinate glutamate receptors across from release sites to control their opening probability. Nanocluster number, size, and prot...

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Literature Corpus work: 9a81b86e-b20f-5139-9ad2-273e415e7226
DOI: 10.1101/2024.01.12.574705

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