Article
Postsynaptic gephyrin clustering controls the development of adult-born granule cells in the olfactory bulb.
The Journal of comparative neurology - 1 Sept 2015
Deprez Francine, Pallotto Marta, Vogt Fabia, Grabiec Marta, Virtanen Mari A, Tyagarajan Shiva K, Panzanelli Patrizia, Fritschy Jean-Marc
Abstract excerpt
In adult rodent olfactory bulb, GABAergic signaling regulates migration, differentiation, and synaptic integration of newborn granule cells (GCs), migrating from the subventricular zone. Here we show that these effects depend on the formation of a postsynaptic scaffold organized by gephyrin-the main scaffolding protein of GABAergic synapses, which anchors receptors and signaling molecules to the postsynaptic...
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