Article
Differential control of postsynaptic density scaffolds via actin-dependent and -independent mechanisms.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 19 Jul 2006
Kuriu Toshihiko, Inoue Akihiro, Bito Haruhiko, Sobue Kenji, Okabe Shigeo
Abstract excerpt
Organization and dynamic remodeling of postsynaptic density (PSD) are thought to be critical in postsynaptic signal transduction, but the underlying molecular mechanisms are not well understood. We show here that four major scaffolding molecules, PSD-95, GKAP, Shank, and PSD-Zip45, show distinct instability in total molecular content per synapse. Fluorescence recovery after photobleaching also confirmed their...
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