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Article

Bimodal loop-loop interactions increase the affinity of RNA aptamers for HIV-1 RNA structures.

Biochemistry - 7 Feb 2006

Boucard David, Toulmé Jean-Jacques, Di Primo Carmelo

Abstract excerpt

Multiple loop-loop interactions between adjacent RNA hairpins regulate gene expression in different organisms. To demonstrate that such natural interactions could be mimicked for generating RNA ligands that are able to recognize simultaneously at least two structured RNA targets, a double kissing complex model was designed. The target consisted of two HIV-1 transactivating responsive (TAR) RNA variants, BRU and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16445294
DOI: 10.1021/bi051187f

Genes

MAL
SPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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