Article
In vitro evidence that the untranslated leader of the HIV-1 genome is an RNA checkpoint that regulates multiple functions through conformational changes.
The Journal of biological chemistry - 31 May 2002
Berkhout Ben, Ooms Marcel, Beerens Nancy, Huthoff Hendrik, Southern Edwin, Verhoef Koen
Abstract excerpt
The HIV-1 RNA genome forms dimers through base pairing of a palindromic 6-mer sequence that is exposed in the loop of the dimer initiation signal (DIS) hairpin structure (loop-loop kissing). The HIV-1 leader RNA can adopt a secondary structure conformation that is not able to dimerize because the DIS hairpin is not folded. Instead, this DIS motif is base-paired in a long distance interaction (LDI) that extends...
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