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Article

HIV-1 DIS stem loop forms an obligatory bent kissing intermediate in the dimerization pathway.

Nucleic acids research - 1 Jun 2014

Mundigala Hansini, Michaux Jonathan B, Feig Andrew L, Ennifar Eric, Rueda David

Abstract excerpt

The HIV-1 dimerization initiation sequence (DIS) is a conserved palindrome in the apical loop of a conserved hairpin motif in the 5'-untranslated region of its RNA genome. DIS hairpin plays an important role in genome dimerization by forming a 'kissing complex' between two complementary hairpins. Understanding the kinetics of this interaction is key to exploiting DIS as a possible human immunodeficiency virus...

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Identifiers

PMID: 24813449
DOI: 10.1093/nar/gku332
PMCID: PMC4066764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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