Article
A comparative binding study of modified bovine immunodeficiency virus TAR RNA against its TAT peptide.
Bioorganic & medicinal chemistry letters - 20 Dec 2004
Tok Jeffrey B-H, Bi Lanrong, Huang Shuying
Abstract excerpt
Besides generating novel binding peptides or small molecules to their RNA target, successful design of chemically modified RNA constructs capable of tighter binding with their binding peptides is also of significant importance. Herein, the synthesis and binding studies of a series of both wt and mutant bovine immunodeficiency virus (BIV) TAR RNA constructs against its Tat peptide are reported. Understanding the...
Topics
- Animals
- Cattle
- Fluorescence Polarization
- Gene Products, tat
- Immunodeficiency Virus, Bovine
- Models, Molecular
- Molecular Structure
- Mutation
- Peptide Fragments
- Protein Binding
- Protein Structure, Secondary
- RNA, Viral
- Structure-Activity Relationship
- Substrate Specificity