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Article

Impact of a Single Nucleotide Change or Non-Nucleoside Modifications in G-Rich Region on the Quadruplex-Duplex Hybrid Formation.

Biomolecules - 18 Aug 2021

Gudanis Dorota, Zielińska Karolina, Baranowski Daniel, Kierzek Ryszard, Kozłowski Piotr, Gdaniec Zofia

Abstract excerpt

In this paper, a method to discriminate between two target RNA sequences that differ by one nucleotide only is presented. The method relies on the formation of alternative structures, i.e., quadruplex-duplex hybrid (QDH) and duplex with dangling ends (Dss), after hybridization of DNA or RNA G-rich oligonucleotides with target sequences containing 5'-GGGCUGG-3' or 5'-GGGCGGG-3' fragments. Using biophysical...

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Identifiers

PMID: 34439902
DOI: 10.3390/biom11081236
PMCID: PMC8392043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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