Article
An Arg/Lys-rich core peptide mimics TRBP binding to the HIV-1 TAR RNA upper-stem/loop.
Journal of molecular biology - 26 Jun 1998
Erard M, Barker D G, Amalric F, Jeang K T, Gatignol A
Abstract excerpt
TRBP is a cellular protein that binds to the HIV-1 leader RNA, TAR. Circular dichroism experiments have shown that a 24 amino acid peptide (TR1), located within a dsRNA binding domain (dsRBD) of TRBP, binds TAR with a 3:1 stoichiometry, eliciting a conformational change involving base unstacking....
Topics
- Amino Acid Sequence
- HIV Long Terminal Repeat
- HIV-1
- Models, Molecular
- Molecular Mimicry
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Peptides
- Protein Conformation
- RNA, Viral
- RNA-Binding Proteins
- Sequence Alignment
- Sequence Homology, Amino Acid