Article
Secondary structure dimorphism and interconversion between hairpin and duplex form of oligoribonucleotides.
Antisense & nucleic acid drug development - 1 Dec 1998
Kirchner R, Vogtherr M, Limmer S, Sprinzl M
Abstract excerpt
RNA hairpins can alternatively form a dimer with a bulged loop flanked by regularly base paired regions. [1H]NMR spectroscopy and native gel electrophoresis were used to study how the sequence of nucleotides in the loop of the hairpin affect the hairpin-duplex interconversion. As a model system,...
Topics
- Base Sequence
- Dimerization
- Kinetics
- Magnetic Resonance Spectroscopy
- Mutation
- Nucleic Acid Conformation
- RNA, Transfer, Ala