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Article

Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing.

Nature - 26 Jan 2006

Ferres-Marco Dolors, Gutierrez-Garcia Irene, Vallejo Diana M, Bolivar Jorge, Gutierrez-Aviño Francisco J, Dominguez Maria

Abstract excerpt

Cancer is both a genetic and an epigenetic disease. Inactivation of tumour-suppressor genes by epigenetic changes is frequently observed in human cancers, particularly as a result of the modifications of histones and DNA methylation. It is therefore important to understand how these damaging changes might come about. By studying tumorigenesis in the Drosophila eye, here we identify two Polycomb group epigenetic...

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PMID: 16437107
DOI: 10.1038/nature04376

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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