Article
Histone H3.3 K27M and K36M mutations de-repress transposable elements through perturbation of antagonistic chromatin marks.
Molecular cell - 2 Dec 2021
Chaouch Amel, Berlandi Johannes, Chen Carol C L, Frey Felice, Badini Shireen, Harutyunyan Ashot S, Chen Xiao, Krug Brian, Hébert Steven, Jeibmann Astrid, Lu Chao, Kleinman Claudia L, Hasselblatt Martin, Lasko Paul, Shirinian Margret, Jabado Nada
Abstract excerpt
Histone H3.3 lysine-to-methionine substitutions K27M and K36M impair the deposition of opposing chromatin marks, H3K27me3/me2 and H3K36me3/me2. We show that these mutations induce hypotrophic and disorganized eyes in Drosophila eye primordia. Restriction of H3K27me3 spread in H3.3K27M and its redistribution in H3.3K36M result in transcriptional deregulation of PRC2-targeted eye development and of piRNA biogenesis...
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