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Article

Lin9, a subunit of the mammalian DREAM complex, is essential for embryonic development, for survival of adult mice, and for tumor suppression.

Molecular and cellular biology - 1 Jun 2010

Reichert Nina, Wurster Sebastian, Ulrich Tanja, Schmitt Kathrin, Hauser Stefanie, Probst Leona, Götz Rudolf, Ceteci Fatih, Moll Roland, Rapp Ulf, Gaubatz Stefan

Abstract excerpt

The retinoblastoma tumor suppressor protein (pRB) and related p107 and p130 "pocket proteins" function together with the E2F transcription factors to repress gene expression during the cell cycle and development. Recent biochemical studies have identified the multisubunit DREAM pocket protein com...

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Source

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Identifiers

PMID: 20404087
DOI: 10.1128/MCB.00028-10
PMCID: PMC2876665

Genes

LIN9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20404087-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Lin9, a subunit of the mammalian DREAM complex, is essential for embryonic development, for survival of adult mice, and for tumor suppression.PMID 20404087Read ↗

Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence.Semantic proximity Read ↗

LINC, a Human Complex That is Related to pRB-Containing Complexes in Invertebrates Regulates the Expression of G<sub>2</sub>/M GenesSemantic proximity Read ↗

DREAM interrupted: severing LIN-35-MuvB association in Caenorhabditis elegans impairs DREAM function but not its chromatin localization.Semantic proximity Read ↗

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Loss of the mammalian DREAM complex deregulates chondrocyte proliferation.Semantic proximity Read ↗

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RB, the conductor that orchestrates life, death and differentiation.Semantic proximity Read ↗

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