Article
Dynamic regulation by polycomb group protein complexes controls pattern formation and the cell cycle in Drosophila.
Developmental cell - 1 Dec 2008
Oktaba Katarzyna, Gutiérrez Luis, Gagneur Julien, Girardot Charles, Sengupta Aditya K, Furlong Eileen E M, Müller Jürg
Abstract excerpt
Polycomb group (PcG) proteins form conserved regulatory complexes that modify chromatin to repress transcription. Here, we report genome-wide binding profiles of PhoRC, the Drosophila PcG protein complex containing the DNA-binding factor Pho/dYY1 and dSfmbt. PhoRC constitutively occupies short Polycomb response elements (PREs) of a large set of developmental regulator genes in both embryos and larvae. The...
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