Article

Dysfunction of the Polycomb protein RYBP and of 5-methylcytosine oxidases leads to widespread CpG island hypermethylation and cell transformation

2022-07-27

Abstract excerpt

<h4>ABSTRACT</h4> DNA hypermethylation is a hallmark of cancer and predominantly affects CpG island regions. Although this phenomenon was first described more than three decades ago, its mechanisms have remained unknown. Since CpG island hypermethylation is strongly biased towards Polycomb target genes, we reasoned that dysfunction of Polycomb repression complexes (PRCs) may underlie CpG island hypermethylation....

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Literature Corpus work: fc3f8920-767b-52a5-b144-63689f47065a
DOI: 10.1101/2022.07.26.501603

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