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Article

Knockdown of PR-DUB subunit calypso in the developing Drosophila eye and wing results in mis-patterned tissues with altered size and shape.

G3 (Bethesda, Md.) - 10 Dec 2025

Luf Max, Begani Priya, Bowcock Anne M, Pfleger Cathie M

Abstract excerpt

The deubiquitinating enzyme BAP1 is the catalytic subunit of the Polycomb Repressive Deubiquitinase (PR-DUB) complex, which acts with the Polycomb Repressive Complexes 1 and 2 to regulate chromatin organization to repress homeotic genes and other developmental regulators. Loss of BAP1 is implicated in several cancers, in the familial cancer syndrome BAP1 Tumor Predisposition Syndrome, and in the...

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Identifiers

PMID: 41022584
DOI: 10.1093/g3journal/jkaf227
PMCID: PMC12693516

Genes

BAP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Knockdown of PR-DUB subunit calypso in the developing Drosophila eye and wing results in mis-patterned tissues with altered size and shape.PMID 41022584Read ↗

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