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Article

Paradoxical instability-activity relationship defines a novel regulatory pathway for retinoblastoma proteins.

Molecular biology of the cell - 15 Nov 2010

Acharya Pankaj, Raj Nitin, Buckley Martin S, Zhang Liang, Duperon Stephanie, Williams Geoffrey, Henry R William, Arnosti David N

Abstract excerpt

The retinoblastoma (RB) transcriptional corepressor and related family of pocket proteins play central roles in cell cycle control and development, and the regulatory networks governed by these factors are frequently inactivated during tumorigenesis. During normal growth, these proteins are subject to tight control through at least two mechanisms. First, during cell cycle progression, repressor potential is...

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Identifiers

PMID: 20861300
DOI: 10.1091/mbc.E10-06-0520
PMCID: PMC2982090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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