Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutating RBF can enhance its pro-apoptotic activity and uncovers a new role in tissue homeostasis.

PloS one - 1 Jan 2014

Milet Cécile, Rincheval-Arnold Aurore, Moriéras Angéline, Clavier Amandine, Garrigue Alexandrine, Mignotte Bernard, Guénal Isabelle

Abstract excerpt

The tumor suppressor retinoblastoma protein (pRb) is inactivated in a wide variety of cancers. While its role during cell cycle is well characterized, little is known about its properties on apoptosis regulation and apoptosis-induced cell responses. pRb shorter forms that can modulate pRB apoptotic properties, resulting from cleavages at caspase specific sites are observed in several cellular contexts. A...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caspases
Share to Consensus Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Imaginal Discs

Share to MAP Kinase Signaling System

Share to Organ Specificity

Share to Retinoblastoma Protein

Share to Wings, Animal

Share to Wnt1 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 25089524
DOI: 10.1371/journal.pone.0102902
PMCID: PMC4121136

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutating RBF can enhance its pro-apoptotic activity and uncovers a new role in tissue homeostasis.PMID 25089524Read ↗

Regulation of apoptosis of rbf mutant cells during Drosophila development.Semantic proximity Read ↗

A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosis.Semantic proximity Read ↗

Conserved RB functions in development and tumor suppressionSemantic proximity Read ↗

Paradoxical instability-activity relationship defines a novel regulatory pathway for retinoblastoma proteins.Semantic proximity Read ↗

Novel roles of plant RETINOBLASTOMA-RELATED (RBR) protein in cell proliferation and asymmetric cell divisionSemantic proximity Read ↗

Integrated stability and activity control of the Drosophila Rbf1 retinoblastoma protein.Semantic proximity Read ↗

Control of apoptosis by Drosophila DCAF12.Semantic proximity Read ↗

Synthetic lethality of retinoblastoma mutant cells in the Drosophila eye by mutation of a novel peptidyl prolyl isomerase gene.Semantic proximity Read ↗

The pro-apoptotic activity of Drosophila Rbf1 involves dE2F2-dependent downregulation of diap1 and buffy mRNA.Semantic proximity Read ↗

The components of Drosophila histone chaperone dCAF-1 are required for the cell death phenotype associated with rbf1 mutation.Semantic proximity Read ↗

RBF and Rno promote photoreceptor differentiation onset through modulating EGFR signaling in the Drosophila developing eye.Semantic proximity Read ↗

The role of RBF in developmentally regulated cell proliferation in the eye disc and in Cyclin D/Cdk4 induced cellular growth.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.