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Article

Identification of the amino acid residues rendering TI-VAMP insensitive toward botulinum neurotoxin B.

Journal of molecular biology - 24 Mar 2006

Sikorra Stefan, Henke Tina, Swaminathan Subramanyam, Galli Thierry, Binz Thomas

Abstract excerpt

Botulinum neurotoxins types B, D, F, and G, and tetanus neurotoxin inhibit vesicular fusion via proteolytic cleavage of VAMP/Synaptobrevin, a core component of the membrane fusion machinery. Thus, these neurotoxins became widely used tools for investigating vesicular trafficking routes. Except for VAMP-1, VAMP-2, and Cellubrevin, no other member of the VAMP family represents a substrate for these neurotoxins. The...

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Identifiers

PMID: 16430921
DOI: 10.1016/j.jmb.2005.12.075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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