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Article

Identification of the SV2 protein receptor-binding site of botulinum neurotoxin type E.

The Biochemical journal - 1 Jul 2013

Mahrhold Stefan, Strotmeier Jasmin, Garcia-Rodriguez Consuelo, Lou Jianlong, Marks James D, Rummel Andreas, Binz Thomas

Abstract excerpt

The highly specific binding and uptake of BoNTs (botulinum neurotoxins; A-G) into peripheral cholinergic motoneurons turns them into the most poisonous substances known. Interaction with gangliosides accumulates the neurotoxins on the plasma membrane and binding to a synaptic vesicle membrane protein leads to neurotoxin endocytosis. SV2 (synaptic vesicle glycoprotein 2) mediates the uptake of BoNT/A and /E,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23621114
DOI: 10.1042/BJ20130391

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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