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Article

Synaptobrevin/vesicle-associated membrane protein (VAMP) of Aplysia californica: structure and proteolysis by tetanus toxin and botulinal neurotoxins type D and F.

Proceedings of the National Academy of Sciences of the United States of America - 24 May 1994

Yamasaki S, Hu Y, Binz T, Kalkuhl A, Kurazono H, Tamura T, Jahn R, Kandel E, Niemann H

Abstract excerpt

Synaptobrevin/vesicle-associated membrane protein (VAMP) and syntaxin are potential vesicle donor and target membrane receptors of a docking complex that requires N-ethylmaleimide-sensitive factor (NSF) and soluble NSF-attachment proteins as soluble factors for vesicle fusion with target membranes. Members of this docking complex are the target of clostridial neurotoxins that act as zinc-dependent proteases....

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Identifiers

PMID: 8197120
DOI: 10.1073/pnas.91.11.4688
PMCID: PMC43853

Genes

NSF

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Synaptobrevin/vesicle-associated membrane protein (VAMP) of Aplysia californica: structure and proteolysis by tetanus toxin and botulinal neurotoxins type D and F.PMID 8197120Read ↗

Structure and function of tetanus and botulinum neurotoxinsSemantic proximity Read ↗

Cleavage of members of the synaptobrevin/VAMP family by types D and F botulinal neurotoxins and tetanus toxin.Semantic proximity Read ↗

Botulinum Toxin: A Comprehensive Review of Its Molecular Architecture and Mechanistic ActionSemantic proximity Read ↗

Functional characterisation of tetanus and botulinum neurotoxins binding domainsSemantic proximity Read ↗

Identification of the amino acid residues rendering TI-VAMP insensitive toward botulinum neurotoxin B.Semantic proximity Read ↗

Identification of the SV2 protein receptor-binding site of botulinum neurotoxin type E.Semantic proximity Read ↗

The C2A domain of synaptotagmin alters the kinetics of voltage-gated Ca2+ channels Ca(v)1.2 (Lc-type) and Ca(v)2.3 (R-type).Semantic proximity Read ↗

The calcium-binding loops of the tandem C2 domains of synaptotagmin VII cooperatively mediate calcium-dependent oligomerization.Semantic proximity Read ↗

High Conservation of Tetanus and Botulinum Neurotoxins Cleavage Sites on Human SNARE Proteins Suggests That These Pathogens Exerted Little or No Evolutionary Pressure on Humans.Semantic proximity Read ↗

Regulation of neuronal SNARE assembly by the membrane.Semantic proximity Read ↗

Ca(2+)-independent syntaxin binding to the C(2)B effector region of synaptotagmin.Semantic proximity Read ↗

Recruitment of septin cytoskeletal proteins by botulinum toxin A protease determines its remarkable stability.Semantic proximity Read ↗

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