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Article

Structure and function of tetanus and botulinum neurotoxins

1 Nov 1995

Abstract excerpt

Tetanus and botulinum neurotoxins are produced by Clostridia and cause the neuroparalytic syndromes of tetanus and botulism. Tetanus neurotoxin acts mainly at the CNS synapse, while the seven botulinum neurotoxins act peripherally. Clostridial neurotoxins share a similar mechanism of cell intoxication: they block the release of neurotransmitters. They are composed of two disulfide-linked polypeptide chains. The...

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PMID: 8771234
DOI: 10.1017/s0033583500003292

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