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Article

Comparative characterization of botulinum neurotoxin subtypes F1 and F7 featuring differential substrate recognition and cleavage mechanisms.

Toxicon : official journal of the International Society on Toxinology - 1 Mar 2016

Guo Jiubiao, Chan Edward Wai Chi, Chen Sheng

Abstract excerpt

BoNT/F7, one of the seven subtypes of botulinum neurotoxin type F (F1 to F7), is the second-most divergent subtype of this group. Despite sharing >60% identity with BoNT/F1 at both holotoxin and enzymatic domain levels, it requires an N-terminal extended peptide substrate for efficient substrate cleavage, suggesting its unique substrate recognition and specificity mechanism. Substrate mapping and saturation...

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Identifiers

PMID: 26748154
DOI: 10.1016/j.toxicon.2015.12.020

Genes

VAMP2

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