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Article

Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins.

PLoS pathogens - 1 Jul 2014

Peng Lisheng, Adler Michael, Demogines Ann, Borrell Andrew, Liu Huisheng, Tao Liang, Tepp William H, Zhang Su-Chun, Johnson Eric A, Sawyer Sara L, Dong Min

Abstract excerpt

Botulinum neurotoxins (BoNT/A-G), the most potent toxins known, act by cleaving three SNARE proteins required for synaptic vesicle exocytosis. Previous studies on BoNTs have generally utilized the major SNARE homologues expressed in brain (VAMP2, syntaxin 1, and SNAP-25). However, BoNTs target pe...

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Source

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Identifiers

PMID: 25010769
DOI: 10.1371/journal.ppat.1004177
PMCID: PMC4092145

Genes

VAMP1
VAMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25010769-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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