Cleavage of members of the synaptobrevin/VAMP family by types D and F botulinal neurotoxins and tetanus toxin.

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Article

Cleavage of members of the synaptobrevin/VAMP family by types D and F botulinal neurotoxins and tetanus toxin.

The Journal of biological chemistry - 29 Apr 1994

Yamasaki S, Baumeister A, Binz T, Blasi J, Link E, Cornille F, Roques B, Fykse E M, Südhof T C, Jahn R

Abstract excerpt

Tetanus toxin (TeTx) and the various forms of botulinal neurotoxins (BoNT/A to BoNT/G) potently inhibit neurotransmission by means of their L chains which selectively proteolyze synaptic proteins such as synaptobrevin (TeTx, BoNT/B, BoNT/F), SNAP-25 (BoNT/A), and syntaxin (BoNT/C1). Here we show...

Topics

Amino Acid Sequence
Animals
Base Sequence
Binding Sites
Botulinum Toxins
DNA Primers
Hydrolysis
Membrane Proteins
Molecular Sequence Data
Mutation
Nerve Tissue Proteins
R-SNARE Proteins
Rats
Tetanus Toxin

Source

Open in PubMed

Identifiers

PMID: 8175689

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8175689-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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